Libuda Lab | Publications | Genetics, Genomics, Meiosis

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Publication-associated resources

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Acadia L. DiNardo, Nicole A. Kurhanewicz, and Diana E. Libuda*. Caenorhabditis elegans form sexually dimorphic and dynamic germ granules throughout meiotic prophase I progression.

Mol Biol Cell in minor revisions

bioRxiv [Preprint] 2026 doi: https://doi.org/10.64898/2026.04.27.721164

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Zachary D. Bush, John S. Conery, Hannah R. Wilson, Alice F.S. Naftaly, Devin Dinwiddie, Kenneth J. Hillers, and Diana E. Libuda*. High resolution global recombination mapping in C. elegans reveals sexual dimorphisms shaped by meiotic chromosomal features and structures.

PLOS Genetics, 2026 Jul 14;22(7):e1012237 doi: https://doi.org/10.1371/journal.pgen.1012237

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Zachary D. Bush, Alice F.S. Naftaly, Devin Dinwiddie, Kenneth J. Hillers, and Diana E. Libuda*. Genomic sequence and structural variation accumulation between wild type laboratory lineages of C. elegans.

bioRxiv [Preprint] 2026 doi: https://doi.org/10.64898/2026.04.27.720957

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Acadia L. DiNardo, Nicole A. Kurhanewicz, Hannah R. Wilson, Veronica Berg, and Diana E. Libuda*. WAGO-1 is a sexually dimorphic Argonaute protein required for proper germ granule structure and gametogenesis.

bioRxiv [Preprint] 2025 Jun 1:2025.05/29.656876. doi: https://doi.org/10.1101/2025.05.29.656876

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Zachary D. Bush, Alice S. Naftaly, Devin Dinwiddie, Cora Albers, Kenneth J. Hillers, and Diana E. Libuda*. Transposable elements and heterochromatin regions are enriched for structural variation and sequence divergence in the genome of wild type C. elegans.

G3:Genes|Genomes|Genetics, 2025 Jul 9;15(7):jkaf092. doi: https://doi.org/10.1093/g3journal/jkaf092

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Erik Toraason, Alina Salagean, Jordan Brown, Colette Richter, David Almanzar, Ofer Rog, and Diana E. Libuda*. BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during C. elegans meiosis

eLife, 2024 Aug 8:13:e80687.

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Cori K. Cahoon, Colette M. Richter, Amelia E. Dayton, and Diana E. Libuda*. Sexual dimorphic regulation of recombination by the synaptonemal complex.

eLife, 2023 Oct 5:12:e84538.

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Jamie Ho, Leslie A. Guerrero, Diana E. Libuda, G W Gant Luxton, and Daniel A. Starr*. Actin and CDC-42 contribute to nuclear migration through constricted spaces in C. elegans.

Development, 2023 Oct 1;150(19):dev202115.

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Cori K. Cahoon, Celja J. Uebel, Anne M. Villeneuve, and Diana E. Libuda*. Epitope tag-specific differences in the detection of COSA-1 marked crossover sites in C. elegans spermatocytes.

MicroPublication Biology, 2023

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Erik Toraason, Victoria L. Alder, and Diana E. Libuda (2022). Aging and sperm signals alter DNA break formation and repair in the C. elegans germline.

PLOS Genetics, 2022 Nov 7;18(11):e1010282.

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Erik Toraason, Anna Horacek, Cordell Clark, Marissa L. Glover, Victoria L. Adler, Tolkappiyan Premkumar, Alina Salagean, Francesca Cole, and Diana E. Libuda. Meiotic DNA break repair can utilize homolog-independent templates in C. elegans.

Current Biology, 2021 Apr 12;31(7):1508- 1514.e5.

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Erik Toraason, Victoria L. Adler, Nicole A. Kurhanewicz, Acadia DiNardo, Adam M. Saunders, Cori K. Cahoon, and Diana E. Libuda. Automated and customizable quantitative image analysis of whole C. elegans germlines.

Genetics 2021 Jan 23;217(3):iyab010.

(featured article in March 2021 issue of Genetics)

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Cori K. Cahoon and Diana E. Libuda. Conditional immobilization for live imaging C. elegans using auxin-dependent protein depletion.

G3:Genes|Genomes|Genetics, 2021 Oct 19; 11(11):jkab310.

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Erik Toraason, Marissa L. Glover, Anna Horacek, and Diana E. Libuda. Detection of homolog- independent meiotic DNA repair events in C. elegans with the Intersister/Intrachromatid Repair (ICR) Assay.

STAR Protocols 2021 Sept 17; 2(100801).

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Nicole A. Kurhanewicz, Devin Dinwiddie, Zachary Bush, and Diana E. Libuda*. Elevated temperatures cause transposon-associated DNA damage in spermatocytes.

Current Biology 2020 Dec 21;30(24):5007-5017.e4.

(featured in a Dispatch/Perspective article by N. Bhalla in Current Biology)

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Jeremy A. Hollis, Marissa L. Glover, Aleesa Schlientz, Cori K. Cahoon, Bruce Bowerman, Sadie M. Wignall*, and Diana E. Libuda*. Excess crossovers impede faithful meiotic chromosome segregation in C. elegans.

PLOS Genetics, 2020 Sep 4;16(9):e1009001.

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Cori K. Cahoon, Jacquellyn M. Helm, and Diana E. Libuda*. Synaptonemal complex central region proteins promote localization of pro- crossover factors to recombination events during Caenorhabditis elegans meiosis.

Genetics, 2019 Oct;213(2):395-409.

(highlighted by Genetics editorial board in the published issue)

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Mara Schvarzstein, Divya Pattabiraman, Diana E. Libuda, Ajit Ramadugu, Angela Tam, Enrique Martinez-Perez, Baptiste Roelens, Karl Zawadzki, Rayka Yokoo, Simona Rosu, Kentaro Nabeshima, and Anne M. Villeneuve. DNA helicase HIM-6/BLM promotes MutSγ-dependent crossovers and antagonizes MutSγ-independent interhomolog associations during C. elegans meiosis.

Genetics, 2014 Sep;198(1):193-207

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Diana E. Libuda, Satoru Uzawa, Barbara J. Meyer, and Anne M. Villeneuve. Meiotic chromosome structures constrain and respond to designation of crossover sites.

Nature 2013 Oct 31; 502(7473):703- 6.

(recommended in Faculty of 1000 by Gerald Smith and Mridula Nambiar)

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Simona Rosu, Karl A. Zawadzki, Ericca L. Stamper, Diana E. Libuda, Angela L. Reese, Abby F. Dernburg, and Anne M. Villeneuve. The C. elegans DSB-2 protein reveals a regulatory network that controls competence for meiotic DSB formation.

PLoS Genetics 2013;9(8):e1003674.

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Simona Rosu, Diana E. Libuda, and Anne M. Villeneuve. Robust crossover assurance and regulated interhomolog access maintain meiotic crossover number.

Science, 2011 Dec 2;334(6060):1286-9.

(recommended in Faculty of 1000 by Morris Maduro)

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Diana E. Libuda and Fred Winston. Alterations in DNA replication and histone levels promote histone gene amplification in Saccharomyces cerevisiae.

Genetics, 2010 Apr;184(4):985-97.

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Diana E. Libuda and Fred Winston. Amplification of histone genes by circular chromosome formation in Saccharomyces cerevisiae.

Nature, 2006 Oct 26;443(7114):1003-7.

(recommended in Faculty of 1000 by Linda Breeden)

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Sanja Ivkovic, Byeong S. Yoon, Steven N. Popoff, Fayez F. Safadi, Diana E. Libuda, Robert C. Stephenson, Aaron Daluiski, and Karen M. Lyons. Connective Tissue Growth Factor is an essential regulator of skeletal development.

Development, 2003 Jun;130(12):2779-91.

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Department of Biology | Institute of Molecular Biology

University of Oregon

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Website last updated October 2026 by Shiyu Zhang